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Article

Correlation of Crtc1/3-Maml2 fusion status, grade and survival in mucoepidermoid carcinoma.

Oral oncology - 1 May 2017

Birkeland Andrew C, Foltin Susan K, Michmerhuizen Nicole L, Hoesli Rebecca C, Rosko Andrew J, Byrd Serena, Yanik Megan, Nor Jacques E, Bradford Carol R, Prince Mark E, Carey Thomas E, McHugh Jonathan B, Spector Matthew E, Brenner J Chad

Abstract excerpt

OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Tumor stage and grade have historically been important predictors of survival. An oncogenic CRTC1- or CRTC3-MAML2 gene fusion has been identified in a number of MECs. Historically, these gene fusions have been associated with lower grade tumors and better survival. However, reported gene fusion rates and prognosis...

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Identifiers

PMID: 28438292
DOI: 10.1016/j.oraloncology.2017.02.025
PMCID: PMC5433350

Genes

CRTC1
MAML2
CRTC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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