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Article

The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma

7 Apr 2021

Abstract excerpt

No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC is frequently associated with a t(11;19)(q14-21;p12-13) translocation that creates a CRTC1-MAML2 fusion gene. The CRTC1-MAML2 fusion exhibited transforming activity in vitro; however, whether it serves as an oncogenic driver for MEC...

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PMID: 33830080
DOI: 10.1172/jci.insight.139497

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