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Article

The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway.

Brain, behavior, and immunity - 1 Mar 2021

Valencia Braulio M, Cvejic Erin, Vollmer-Conna Ute, Hickie Ian B, Wakefield Denis, Li Hui, Pedergnana Vincent, Rodrigo Chaturaka, Lloyd Andrew R

Abstract excerpt

The acute sickness response (ASR) is a stereotyped set of symptoms including fatigue, pain, and disturbed mood, which are present in most acute infections. The immunological mechanisms of the ASR are conserved, with variations in severity determined partly by the pathogen, but also by polymorphisms in host genes. The ASR was characterised in three different serologically-confirmed acute infections in Caucasians...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33434563
DOI: 10.1016/j.bbi.2021.01.005
PMCID: PMC7794598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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