Article
Genome-Wide Analysis Unveils DNA Helicase RECQ1 as a Regulator of Estrogen Response Pathway in Breast Cancer Cells.
Molecular and cellular biology - 24 Mar 2021
Lu Xing, Redon Christophe E, Tang Wei, Parvathaneni Swetha, Bokhari Bayan, Debnath Subrata, Li Xiao Ling, Muys Bruna R, Song Young, Pongor Lorinc S, Sheikh Omar, Green Andrew R, Madhusudan Srinivasan, Lal Ashish, Ambs Stefan, Khan Javed, Aladjem Mirit I, Sharma Sudha
Abstract excerpt
Susceptibility to breast cancer is significantly increased in individuals with germ line mutations in RECQ1 (also known as RECQL or RECQL1), a gene encoding a DNA helicase essential for genome maintenance. We previously reported that RECQ1 expression predicts clinical outcomes for sporadic breast cancer patients stratified by estrogen receptor (ER) status. Here, we utilized an unbiased integrative genomics...
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