Article
The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma.
BMC cancer - 19 Jan 2021
Kang Jin Hyun, Lee Seung Ho, Lee Jawon, Choi Murim, Cho Junhun, Kim Seok Jin, Kim Won Seog, Ko Young Hyeh, Yoo Hae Yong
Abstract excerpt
BACKGROUND: BCOR acts as a corepressor of BCL6, a potent oncogenic protein in cancers of the lymphoid lineage. We have found the recurrent somatic mutation of BCOR occurred in mature T-cell lymphoma (TCL). The role of BCOR mutation in lymphoid malignancies is unknown. METHODS: Lymphoma patient samples were analyzed to identify missense mutations in BCOR using Sanger sequencing. Transfection, RNA interference,...
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