Article
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.
Molecular cell - 15 Feb 2008
Ghetu Alexandru F, Corcoran Connie M, Cerchietti Leandro, Bardwell Vivian J, Melnick Ari, Privé Gilbert G
Abstract excerpt
The transcriptional corepressors BCOR, SMRT, and NCoR are known to bind competitively to the BCL6 BTB domain despite the fact that BCOR has no detectable sequence similarity to the other two corepressors. We have identified a 17 residue motif from BCOR that binds directly to the BCL6 BTB domain and determined the crystal structure of the complex to a resolution of 2.6 A. Remarkably, the BCOR BCL6 binding domain...
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