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Article

BCOR gene alterations in hematologic diseases.

Blood - 16 Dec 2021

Sportoletti Paolo, Sorcini Daniele, Falini Brunangelo

Abstract excerpt

The BCL6 corepressor (BCOR) is a transcription factor involved in the control of embryogenesis, mesenchymal stem cells function, hematopoiesis, and lymphoid development. Recurrent somatic clonal mutations of the BCOR gene and its homolog BCORL1 have been detected in several hematologic malignancies and aplastic anemia. They are scattered across the whole gene length and mostly represent frameshifts (deletions,...

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Identifiers

PMID: 33945606
DOI: 10.1182/blood.2021010958
PMCID: PMC8887995

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