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Article

BTG1 inactivation drives lymphomagenesis and promotes lymphoma dissemination through activation of BCAR1.

Blood - 9 Mar 2023

Delage Lorric, Lambert Mireille, Bardel Émilie, Kundlacz Cindy, Chartoire Dimitri, Conchon Axel, Peugnet Anne-Laure, Gorka Lucas, Auberger Patrick, Jacquel Arnaud, Soussain Carole, Destaing Olivier, Delecluse Henri-Jacques, Delecluse Susanne, Merabet Samir, Traverse-Glehen Alexandra, Salles Gilles, Bachy Emmanuel, Billaud Marc, Ghesquières Hervé, Genestier Laurent, Rouault Jean-Pierre, Sujobert Pierre

Abstract excerpt

Understanding the functional role of mutated genes in cancer is required to translate the findings of cancer genomics into therapeutic improvement. BTG1 is recurrently mutated in the MCD/C5 subtype of diffuse large B-cell lymphoma (DLBCL), which is associated with extranodal dissemination. Here, we provide evidence that Btg1 knock out accelerates the development of a lethal lymphoproliferative disease driven by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Lymphoma, Large B-Cell, Diffuse

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Source

Identifiers

PMID: 36375119
DOI: 10.1182/blood.2022016943

Genes

BTG1
BCAR1
C5
RAC1
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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