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Article

A novel isoform of the B cell tyrosine kinase BTK protects breast cancer cells from apoptosis

3 Aug 2013

Abstract excerpt

Tyrosine kinases orchestrate key cellular signaling pathways and their dysregulation is often associated with cellular transformation. Several recent cases in which inhibitors of tyrosine kinases have been successfully used as anticancer agents have underscored the importance of this class of proteins in the development of targeted cancer therapies. We have carried out a large-scale loss-of-function analysis of...

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PMID: 23913792
DOI: 10.1002/gcc.22091

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