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Article

Genetic loci shared between major depression and intelligence with mixed directions of effect.

Nature human behaviour - 1 Jun 2021

Bahrami Shahram, Shadrin Alexey, Frei Oleksandr, O'Connell Kevin S, Bettella Francesco, Krull Florian, Fan Chun C, Røssberg Jan I, Hindley Guy, Ueland Torill, Dale Anders M, Djurovic Srdjan, Steen Nils Eiel, Smeland Olav B, Andreassen Ole A

Abstract excerpt

Genome-wide association studies (GWAS) have identified several common genetic variants influencing major depression and general cognitive abilities, but little is known about whether the two share any of their genetic aetiology. Here we investigate shared genomic architectures between major depression (MD) and general intelligence (INT) with the MiXeR statistical tool and their overlapping susceptibility loci...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33462475
DOI: 10.1038/s41562-020-01031-2
PMCID: PMC8217082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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