Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.

doi:10.1038/ng.3869

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Article

Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence.

Nature genetics - 1 Jul 2017

Sniekers Suzanne, Stringer Sven, Watanabe Kyoko, Jansen Philip R, Coleman Jonathan R I, Krapohl Eva, Taskesen Erdogan, Hammerschlag Anke R, Okbay Aysu, Zabaneh Delilah, Amin Najaf, Breen Gerome, Cesarini David, Chabris Christopher F, Iacono William G, Ikram M Arfan, Johannesson Magnus, Koellinger Philipp, Lee James J, Magnusson Patrik K E, McGue Matt, Miller Mike B, Ollier William E R, Payton Antony, Pendleton Neil, Plomin Robert, Rietveld Cornelius A, Tiemeier Henning, van Duijn Cornelia M, Posthuma Danielle

Abstract excerpt

Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the...

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PMID: 28530673
DOI: 10.1038/ng.3869
PMCID: PMC5665562

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