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Article

IKK epsilon kinase is crucial for viral G protein-coupled receptor tumorigenesis

14 Jun 2013

Abstract excerpt

G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that transmit diverse extracellular signals across a membrane. Herpesvirus genomes encode multiple GPCRs implicated in viral pathogenesis. Kaposi sarcoma-associated herpesvirus GPCR (kGPCR) activates proliferative pathways and, when expressed in endothelium in mice, sufficiently induces angiogenic tumor resembling human Kaposi's sarcoma. IKKε,...

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PMID: 23771900
DOI: 10.1073/pnas.1219829110

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