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Article

3-Dimensional JEG-3 choriocarcinoma cell organoids as a model for trophoblast expansion and differentiation

28 Dec 2020

Abstract excerpt

JEG-3 choriocarcinoma cells have been widely used as a model for placental trophoblast. Herein, 3-dimensional (3D) JEG-3 organoids (JEG-3-ORGs) were established using a protocol that we recently developed for primary cytotrophoblast organoids (CTB-ORGs). 3D JEG-3-ORGs, cultivated in basic culture medium, rapidly divide and spontaneously undergo differentiation. Under stem cell culture conditions (activation of...

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PMID: 33461068
DOI: 10.1016/j.placenta.2020.12.013

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