Reconstructing the emergence of the human chorion via HIPPO-mediated trophoblast induction

Abstract excerpt

The first lineage decision in the mammalian blastocyst commits outer cells to the trophectoderm and initiates the trajectory that gives rise to the placental chorion. The molecular sequence that unfolds downstream of HIPPO pathway inactivation, linking human trophectoderm specification to the early organization of the chorion, has remained unknown. Here, we establish a developmentally informed model that leverages...

Topics

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• Birth, Development, and Health
• Neonatal Respiratory Health Research
• Pluripotent Stem Cells Research
• Pregnancy and preeclampsia studies
• Renal and related cancers
• Reproductive System and Pregnancy
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

554ee8b1-6720-577b-8ae0-789d46e401c0

DOI

10.1101/2025.11.18.688276