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Development of apical out trophoblast stem cell derived organoids to model early human pregnancy

25 Feb 2025

Abstract excerpt

The development of trophoblast organoids has enabled investigation of placental physiology, disease, and early maternal-fetal interactions during a previously restricted stage of pregnancy. A key shortcoming in existing trophoblast organoid methodologies is the non-physiologic position of the syncytiotrophoblast (STB) within the inner portion of the organoid, which neither recapitulates in vivo placental villous...

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PMID: 40129708
DOI: 10.1016/j.isci.2025.112099

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