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Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts

19 Aug 2021

Abstract excerpt

Human trophoblast stem cells (hTSC) can be isolated from first trimester placenta but not from term placenta. Here we demonstrate that villous cytotrophoblasts (vCTB) from term placenta can be reprogrammed into induced trophoblastic stem-like cells (iTSC) by introducing sets of transcription factors. The iTSCs express TSC markers such as GATA3, TEAD4 and ELF5, and are multipotent, validated by their...

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PMID: 34454392
DOI: 10.1016/j.scr.2021.102507

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