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Article

Dysregulated PJA1-TGF-β signaling in cancer stem cell-associated liver cancers

30 Nov 2020

Abstract excerpt

The transforming growth factor beta (TGF-β) signaling pathway plays important roles in cell differentiation, stem cell modulation, organ lineage, and immune suppression. TGF-β signaling is negatively regulated by the ubiquitin-proteasome pathway. Although mouse models of cancer arising from a defective TGF-β pathway clearly demonstrate the tumor-suppressive role of TGF-β, the underlying mechanism by which a...

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PMID: 33457451
DOI: 10.18632/oncoscience.522

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