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Article

Isorhamnetin promotes functional recovery in rats with spinal cord injury by abating oxidative stress and modulating M2 macrophages/microglia polarization.

European journal of pharmacology - 15 Mar 2021

Chen Fei, Hu Minwei, Shen Yue, Zhu Wenjun, Cao Ailin, Ni Bin, Qian Jiao, Yang Jun

Abstract excerpt

Spinal cord injury (SCI), mostly caused by sports injuries, falls, or traffic accidents, is a major cause of disability. The aim of current work was to investigate the therapeutic effect of isorhamnetin (ISO) on functional recovery in rats with SCI. The male adult rats were exposed to a clip-compression SCI and treated with ISO. ISO treatment improved locomotor function and reduced the loss of motor neurons in...

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PMID: 33453223
DOI: 10.1016/j.ejphar.2021.173878

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