Article

Inhibiting HMGB1 attenuates neuronal ferroptosis after spinal cord injury by inhibiting the p38/JNK MAPK signaling pathway

2022-04-01

Abstract excerpt

Neuronal ferroptosis is an important pathological process after spinal cord injury (SCI). High mobility group box-1 protein (HMGB1) could regulate ferroptosis in other diseases. However, the effects of HMGB1 on neuronal ferroptosis after SCI are unclear. In this study, in vitro and in vivo experiments were performed to assess the expression levels of ferroptosis-related genes and proteins, as well as malondialdehy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d06818ce-1396-5a69-aacb-a834e0ca08bd
DOI: 10.21203/rs.3.rs-1492113/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inhibiting HMGB1 attenuates neuronal ferroptosis after spinal cord injury by inhibiting the p38/JNK MAPK signaling pathwayDOI 10.21203/rs.3.rs-1492113/v1Read

Ferrostatin-1 Alleviates White Matter Injury via Decreasing Ferroptosis Following Spinal Cord InjurySemantic proximity Read

Identification of Ferroptotic Genes in Spinal Cord Injury at Different Time Points: Bioinformatics and Experimental ValidationSemantic proximity Read

Bioinformatics analysis and in vivo validation of ferroptosis-related genes in ischemic strokeSemantic proximity Read

The mechanism by which hyperbaric oxygen treatment alleviates spinal cord injury: genome-wide transcriptome analysisSemantic proximity Read

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatformSemantic proximity Read

Bioinformatics analysis of programmed cell death in spinal cord injurySemantic proximity Read

MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1/TLR4/NF-κB pathwaySemantic proximity Read

Zinc deficiency impairs functional recovery after spinal cord injury by promoting NF-κB activity in macrophagesSemantic proximity Read

HIF-2α induces aggravated intervertebral disc degeneration by activating the IL-6/hepcidin-FPN1 axis and promoting ferroptosis in nucleus pulposus cellsSemantic proximity Read

Ferrostatin-1 Inhibits Toll-Like Receptor 4/NF-κB Signaling to Alleviate Intervertebral Disc Degeneration in RatsSemantic proximity Read

NRF2 activation suppresses motor neuron ferroptosis induced by the SOD1G93A mutation and exerts neuroprotection in amyotrophic lateral sclerosis.Semantic proximity Read