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Article

The Dual Role of Gastrodin in Spinal Cord Injury: Microglial Phenotype Switching and Neuronal Survival via PI3K/AKT Activation.

CNS neuroscience & therapeutics - 1 Apr 2026

Feng Jingsheng, Gao Shutao, Hu Yukun, Sheng Weibin

Abstract excerpt

BACKGROUND: Spinal cord injury (SCI) triggers a complex secondary cascade, the defining feature of which is neuroinflammation. This amplifies tissue damage and impedes neurological recovery. Microglial polarization is a critical event in this process, yet effective modulation strategies remain limited. OBJECTIVE: This study aimed to investigate whether gastrodin (GAS), a natural phenolic glycoside, could provide...

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Chromones
Coculture Techniques
Glucosides
Microglia
Morpholines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuroprotective Agents

Proto-Oncogene Proteins c-akt

Spinal Cord Injuries

Source

Open in PubMed Open full text

Identifiers

PMID: 41933445
DOI: 10.1002/cns.70811
PMCID: PMC13052207

Genes

CD86

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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