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Article

Step-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase.

Biochimica et biophysica acta - 1 Jan 2014

Kuznetsova Alexandra A, Kuznetsov Nikita A, Ishchenko Alexander A, Saparbaev Murat K, Fedorova Olga S

Abstract excerpt

BACKGROUND: Extensive structural studies of human DNA glycosylase hOGG1 have revealed essential conformational changes of the enzyme. However, at present there is little information about the time scale of the rearrangements of the protein structure as well as the dynamic behavior of individual amino acids. METHODS: Using pre-steady-state kinetic analysis with Trp and 2-aminopurine fluorescence detection the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24096108
DOI: 10.1016/j.bbagen.2013.09.035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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