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Article

Incidence of liver disease in people with HFE mutations.

Gut - 1 Mar 2000

Willis G, Wimperis J Z, Lonsdale R, Fellows I W, Watson M A, Skipper L M, Jennings B A

Abstract excerpt

BACKGROUND: Most patients with haemochromatosis have mutations of the HFE gene. However, the risk to people with HFE mutations of developing disease manifestations of haemochromatosis is not known. AIMS: To determine the risk of developing cirrhosis and liver cancer in individuals with HFE mutati...

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Share to Hemochromatosis
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Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Infant, Newborn

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Source

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Identifiers

PMID: 10673304
DOI: 10.1136/gut.46.3.401
PMCID: PMC1727850

Genes

HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10673304-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Incidence of liver disease in people with HFE mutations.PMID 10673304Read ↗

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Morbidity, risk of cancer and mortality in 3645 HFE mutations carriers.Semantic proximity Read ↗

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Penetrance of the C28Y/C282Y genotype of the HFE gene.Semantic proximity Read ↗

HFE genotype in patients with hemochromatosis and other liver diseases.Semantic proximity Read ↗

Hepatocellular carcinoma and the penetrance of HFE C282Y mutations: a cross sectional study.Semantic proximity Read ↗

Mutations of the HFE gene in patients with hepatocellular carcinomaSemantic proximity Read ↗

Lack of association between HFE gene mutations and hepatocellular carcinoma in patients with cirrhosis.Semantic proximity Read ↗

The significance of haemochromatosis gene mutations in the general population: implications for screening.Semantic proximity Read ↗

Frequency of Two Common HFE Gene Mutations (C282Y and H63D) in a group of Iranian Patients with Cryptogenic CirrhosisSemantic proximity Read ↗

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