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Article

MAPK pathway activation in pilocytic astrocytoma

12 Dec 2011

Abstract excerpt

Pilocytic astrocytoma (PA) is the most common tumor of the pediatric central nervous system (CNS). A body of research over recent years has demonstrated a key role for mitogen-activated protein kinase (MAPK) pathway signaling in the development and behavior of PAs. Several mechanisms lead to activation of this pathway in PA, mostly in a mutually exclusive manner, with constitutive BRAF kinase activation...

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PMID: 22159586
DOI: 10.1007/s00018-011-0898-9

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