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Article

Adult pilocytic astrocytomas: clinical features and molecular analysis.

Neuro-oncology - 1 Jun 2014

Theeler Brett J, Ellezam Benjamin, Sadighi Zsila S, Mehta Vidya, Tran M Diep, Adesina Adekunle M, Bruner Janet M, Puduvalli Vinay K

Abstract excerpt

BACKGROUND: Adult pilocytic astrocytomas (PAs) are rare and have an aggressive clinical course compared with pediatric patients. Constitutive Ras/RAF/MAPK signaling appears to be an important oncogenic event in sporadic PA. We evaluated clinical data and molecular profiles of adult PAs at our institution. METHODS: We identified 127 adult PAs in our institutional database. Cases with available tissue were tested...

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Identifiers

PMID: 24470550
DOI: 10.1093/neuonc/not246
PMCID: PMC4022218

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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