Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jan 2021

Girgis Hany S, DuPai Cory D, Lund Jessica, Reeder Janina, Guillory Joseph, Durinck Steffen, Liang Yuxin, Kaminker Joshua, Smith Peter A, Skippington Elizabeth

Abstract excerpt

Tandem gene amplification is a frequent and dynamic source of antibiotic resistance in bacteria. Ongoing expansions and contractions of repeat arrays during population growth are expected to manifest as cell-to-cell differences in copy number (CN). As a result, a clonal bacterial culture could comprise subpopulations of cells with different levels of antibiotic sensitivity that result from variable gene dosage....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acinetobacter baumannii
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Genetic Heterogeneity

Share to Nanopore Sequencing

Share to Peptides, Cyclic

Share to Rec A Recombinases

Share to Serine Endopeptidases

Source

Open in PubMed Open full text

Identifiers

PMID: 33443214
DOI: 10.1073/pnas.2021958118
PMCID: PMC7817135

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-molecule nanopore sequencing reveals extreme target copy number heterogeneity in arylomycin-resistant mutants.PMID 33443214Read ↗

The applications and advantages of nanopore sequencing in bacterial antimicrobial resistance surveillance and researchSemantic proximity Read ↗

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq).Semantic proximity Read ↗

Bacterial droplet-based single-cell RNA-seq reveals heterogeneity in bacterial populations and in response to antibiotic perturbationSemantic proximity Read ↗

High-Resolution Detection of Hidden Antibiotic Resistance with the Dilution-and-Delay (DnD) Susceptibility AssaySemantic proximity Read ↗

Single-cell transcriptomic dynamics exposes hidden survival trajectory under antibiotic treatmentSemantic proximity Read ↗

A single upstream mutation of whiB7 underlies amikacin and clarithromycin resistance in Mycobacterium abscessus.Semantic proximity Read ↗

Large mutational target size for rapid emergence of bacterial persistence.Semantic proximity Read ↗

Grand challenge commentary: Exploiting single-cell variation for new antibiotics.Semantic proximity Read ↗

Bacterial phenotypic heterogeneity through the lens of single-cell RNA sequencing.Semantic proximity Read ↗

Nanopore adaptive sampling effectively enriches bacterial plasmidsSemantic proximity Read ↗

High-throughput characterization of mutations in genes that drive clonal evolution using multiplex adaptome capture sequencing.Semantic proximity Read ↗

Genomics of rapid adaptation to antibiotics: convergent evolution and scalable sequence amplification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.