Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis.

Cancer immunology research - 1 Mar 2021

Wang Lei, Yu Shuiliang, Chan Ernest R, Chen Kai-Yuan, Liu Cui, Che Danian, Awadallah Amad, Myers Jay, Askew David, Huang Alex Y, Maillard Ivan, Huang Dan, Xin Wei, Zhou Lan

Abstract excerpt

Conventional dendritic cells (cDC) play a central role in T-cell antitumor responses. We studied the significance of Notch-regulated DC immune responses in a mouse model of colitis-associated colorectal cancer in which there is epithelial downregulation of Notch/Hes1 signaling. This defect phenocopies that caused by GMDS (GDP-mannose 4,6-dehydratase) mutation in human colorectal cancers. We found that, although...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Transplantation
Share to Carbohydrate Epimerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinogenesis

Share to Hydro-Lyases

Share to Ketone Oxidoreductases

Share to Receptor, Notch2

Share to Receptors, CCR7

Share to Transplantation Chimera

Source

Open in PubMed Open full text

Identifiers

PMID: 33441309
DOI: 10.1158/2326-6066.CIR-20-0428
PMCID: PMC7925430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis.PMID 33441309Read ↗

Notch3 signaling promotes colorectal tumor growth by enhancing immunosuppressive cells infiltration in the microenvironmentSemantic proximity Read ↗

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.Semantic proximity Read ↗

Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein.Semantic proximity Read ↗

Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon CancerSemantic proximity Read ↗

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.Semantic proximity Read ↗

NOD2 Suppresses Colorectal Tumorigenesis via Downregulation of the TLR PathwaysSemantic proximity Read ↗

Notch dimerization contributes to maintenance of intestinal homeostasis by a mechanism involving HDAC2Semantic proximity Read ↗

Notch2 and immune function.Semantic proximity Read ↗

Characterization of colonic dendritic cells in normal and colitic mice.Semantic proximity Read ↗

Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells.Semantic proximity Read ↗

Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice.Semantic proximity Read ↗

TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.