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Dysregulation of the MiR-324-5p-CUEDC2 Axis Leads to Macrophage Dysfunction and Is Associated with Colon Cancer

29 May 2014

Abstract excerpt

CUEDC2, a CUE-domain-containing protein, modulates inflammation, but its involvement in tumorigenesis is still poorly understood. Here, we report that CUEDC2 is a key regulator of macrophage function and critical for protection against colitis-associated tumorigenesis. CUEDC2 expression is dramatically upregulated during macrophage differentiation, and CUEDC2 deficiency results in excessive production of...

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PMID: 24882011
DOI: 10.1016/j.celrep.2014.05.007

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