Article
Exposure to phenols, parabens and UV filters: Associations with loss-of-function mutations in the filaggrin gene in men from the general population.
Environment international - 1 Aug 2017
Joensen Ulla N, Jørgensen Niels, Thyssen Jacob P, Petersen Jørgen Holm, Szecsi Pal B, Stender Steen, Andersson Anne-Maria, Skakkebæk Niels E, Frederiksen Hanne
Abstract excerpt
BACKGROUND: Filaggrin is an epidermal protein that is important for normal skin barrier functions. Up to 10% of Europeans and Asians carry filaggrin gene (FLG) loss-of function mutations that appear to facilitate trans-epidermal penetration of certain chemicals. We previously showed that mutation carriers have higher internal exposure to certain phthalates, compared to controls, and hypothesized that they could...
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