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Article

Polymorphisms in CLAUDIN1 and SPINK5 Influence Skin Absorption of Pyrene, Pyrimethanil, and Oxybenzone in Human Volunteers.

Environmental and molecular mutagenesis - 1 Mar 2026

Keysendal Emmy, Johanson Gunnar, Hagvall Lina, Fyhrqvist Nanna, Lindh Christian, Broberg Karin, Liljedahl Emelie Rietz

Abstract excerpt

Absorption of chemicals through the skin affects occupational and environmental exposure to diverse compounds. We previously showed that loss-of-function (null) mutations and low-copy number variants (CNV) of Filaggrin (FLG), which encodes a key skin barrier protein, increased dermal chemical absorption; however, the FLG genotype did not explain all the observed variation. Here, we explore the effects of...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42033032
DOI: 10.1002/em.70050
PMCID: PMC13109691

Genes

FLG
SPINK5
CLDN1
FLG2
IVL
LAMA3
S100A7
TMEM79

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Polymorphisms in CLAUDIN1 and SPINK5 Influence Skin Absorption of Pyrene, Pyrimethanil, and Oxybenzone in Human Volunteers.PMID 42033032Read ↗

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