Article
Associations of filaggrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish Men.
Environmental health perspectives - 1 Apr 2014
Joensen Ulla Nordström, Jørgensen Niels, Meldgaard Michael, Frederiksen Hanne, Andersson Anna-Maria, Menné Torkil, Johansen Jeanne Duus, Carlsen Berit Christina, Stender Steen, Szecsi Pal Bela, Skakkebæk Niels Erik, Rajpert-De Meyts Ewa, Thyssen Jacob P
Abstract excerpt
BACKGROUND: Filaggrin is an epidermal protein that is crucial for skin barrier function. Up to 10% of Europeans and 5% of Asians carry at least one null allele in the filaggrin gene (FLG). Reduced expression of filaggrin in carriers of the null allele is associated with facilitated transfer of allergens across the epidermis. We hypothesized that these individuals may have increased transdermal uptake of endocrine...
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