Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype.

Pharmacological research - 1 Mar 2021

Kim Hyo In, Lee Seungbeom, Lim Juhee, Chung Sungkyun, Koo Tae-Sung, Ji Yu-Geun, Suh Young-Ger, Son Woo Sung, Kim Seok-Ho, Choi Hyun Jin

Abstract excerpt

Brain derived neurotrophic factor (BDNF) promotes maturation of dopaminergic (DAergic) neurons in the midbrain and positively regulates their maintenance and outgrowth. Therefore, understanding the mechanisms regulating the BDNF signaling pathway in DAergic neurons may help discover potential therapeutic strategies for neuropsychological disorders associated with dysregulation of DAergic neurotransmission....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain-Derived Neurotrophic Factor
Share to Dopaminergic Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Microsomes, Liver

Share to Protein Structure, Secondary

Share to Rats, Sprague-Dawley

Share to Receptor, trkB

Share to Receptors, Estrogen

Source

Identifiers

PMID: 33434621
DOI: 10.1016/j.phrs.2021.105423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ERRγ ligand HPB2 upregulates BDNF-TrkB and enhances dopaminergic neuronal phenotype.PMID 33434621Read ↗

ERRγ Ligand Regulates Adult Neurogenesis and Depression-like Behavior in a LRRK2-G2019S-associated Young Female Mouse Model of Parkinson's Disease.Semantic proximity Read ↗

Discovery of new ERRγ agonists regulating dopaminergic neuronal phenotype in SH-SY5Y cells.Semantic proximity Read ↗

Estrogen-related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK3β/NFAT signaling in SH-SY5Y cells.Semantic proximity Read ↗

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s Disease.Semantic proximity Read ↗

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s DiseaseSemantic proximity Read ↗

Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms.Semantic proximity Read ↗

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cellsSemantic proximity Read ↗

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization.Semantic proximity Read ↗

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome miceSemantic proximity Read ↗

Estrogen receptor‐β regulates human tryptophan hydroxylase‐2 through an estrogen response element in the 5′ untranslated regionSemantic proximity Read ↗

Neuronal and behavioral plasticity: the role of serotonin and BDNF systems tandemSemantic proximity Read ↗

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.