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Article

Discovery of new ERRγ agonists regulating dopaminergic neuronal phenotype in SH-SY5Y cells.

Bioorganic chemistry - 1 May 2022

Kim Taewoo, Kim Hyo In, Oh Haejun, Jeon Yoonsu, Shin Hyeyoung, Kim Hyun Su, Lim Juhee, Lim Changjin, Yoo Jakyung, Suh Young-Ger, Son Woo Sung, Choi Hyun Jin, Kim Seok-Ho

Abstract excerpt

The discovery of small molecules that regulate specific neuronal phenotypes is important for the development of new therapeutic candidates for neurological diseases. Estrogen-related receptor γ (ERRγ), an orphan nuclear receptor widely expressed in the central nervous system (CNS), is closely related to the regulation of neuronal metabolism and differentiation. We previously reported that upregulation of ERRγ...

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PMID: 35303621
DOI: 10.1016/j.bioorg.2022.105716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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