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Article

Estrogen receptor‐β regulates human tryptophan hydroxylase‐2 through an estrogen response element in the 5′ untranslated region

19 Aug 2013

Abstract excerpt

In the dorsal raphe nucleus, 17β-estradiol (E2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (Tph2). Although estrogen receptor beta (ERβ) has been localized to Tph2 neurons, little is known about the transcriptional regulation of the Tph2 gene by estrogen. Since the ERβ agonist, diarylpropionitrile (DPN) also increases Tph2 expression,...

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PMID: 24033289
DOI: 10.1111/jnc.12401

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