Article
Monomers of the Escherichia coli SSB-1 mutant protein bind single-stranded DNA.
Journal of molecular biology - 5 Jan 1991
Bujalowski W, Lohman T M
Abstract excerpt
The Escherichia coli wild-type single strand binding (SSB) protein is a stable tetramer that binds to single-stranded (ss) DNA in its role in DNA replication, recombination and repair. The ssb-1 mutation, a substitution of tyrosine for histidine-55 within the SSB-1 protein, destabilizes the tetramer with respect to monomers, resulting in a temperature-sensitive defect in a variety of DNA metabolic processes,...
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