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Article

Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase.

Protein science : a publication of the Protein Society - 1 Sept 2024

Danda Matěj, Klimešová Anna, Kušková Klára, Dostálková Alžběta, Pagáčová Aneta, Prchal Jan, Kapisheva Marina, Ruml Tomáš, Rumlová Michaela

Abstract excerpt

Since the emergence of SARS-CoV-2, mutations in all subunits of the RNA-dependent RNA polymerase (RdRp) of the virus have been repeatedly reported. Although RdRp represents a primary target for antiviral drugs, experimental studies exploring the phenotypic effect of these mutations have been limited. This study focuses on the phenotypic effects of substitutions in the three RdRp subunits: nsp7, nsp8, and nsp12,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39145418
DOI: 10.1002/pro.5103
PMCID: PMC11325161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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