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Plasma Proteome Profiling of a Mouse Model of Breast Cancer Identifies a Set of Up-Regulated Proteins in Common with Human Breast Cancer Cells

27 Feb 2008

Abstract excerpt

We have applied an in-depth quantitative proteomic approach, combining isotopic labeling extensive intact protein separation and mass spectrometry, for high confidence identification of protein changes in plasmas from a mouse model of breast cancer. We hypothesized that a wide spectrum of proteins may be up-regulated in plasma with tumor development and that comparisons with proteins expressed in human breast...

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PMID: 18311905
DOI: 10.1021/pr7007994

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