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High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice

11 Jan 2021

Abstract excerpt

BACKGROUND: Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, some interventional studies in humans and rodents have shown unfavorable changes in glucose homeostasis in response to NCAS consumption. The causative mechanisms are largely unknown, but adverse changes in gut microbiota have been proposed to mediate these...

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PMID: 33431052
DOI: 10.1186/s40168-020-00976-w

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