Article

High dose saccharin supplementation does not induce gut microbiota dysbiosis or glucose intolerance in healthy humans and mice

2020-02-14

Abstract excerpt

<title>Abstract</title> <p>Background : Non-caloric artificial sweeteners (NCAS) are widely used as a substitute for dietary sugars to control body weight or glycemia. Paradoxically, saccharin and other NCAS have been reported to induce glucose intolerance in mice fed a high-fat diet and in a subset of humans by directly inducing unfavorable changes in gut microbiota. These findings have raised concerns about NCA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a11706f0-a09e-5cc6-8dc4-58717826e314
DOI: 10.21203/rs.2.23608/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High dose saccharin supplementation does not induce gut microbiota dysbiosis or glucose intolerance in healthy humans and miceDOI 10.21203/rs.2.23608/v1Read

High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and miceSemantic proximity Read

Sucralose or rebaudioside A at recommended doses did not alter the gut microbiota composition in rats under two dietary conditionsSemantic proximity Read

Low-doses of Sucralose Alters Fecal Microbiota in High-fat Diet Induced Obese RatsSemantic proximity Read

Short-term consumption of sucralose with, but not without, carbohydrate impairs neural and metabolic sensitivity to sugarSemantic proximity Read

β-sitosterol β-D-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onsetSemantic proximity Read

Non-Nutritive Sweeteners and Their Implications on the Development of Metabolic SyndromeSemantic proximity Read

Sucralose Consumption Ablates Cancer Immunotherapy Response through Microbiome DisruptionSemantic proximity Read

Consumption of human-relevant levels of sucrose-water rewires macronutrient uptake and utilization mechanisms in a tissue specific mannerSemantic proximity Read

Comparative network pharmacology of artificial sweeteners to understand Its health consequencesSemantic proximity Read

Gut Microbiota and a Selectively Bred Taste Phenotype: A Novel Model of Microbiome-Behavior Relationships.Semantic proximity Read

Intake of the Artificial Sweetener Acesulfame-Potassium Alone and in Combination with a High-Fat Diet Leads to Differential and Sex-Specific Effects on Metabolic Function in MiceSemantic proximity Read

Sucrose, glucose and fructose have similar genotoxicity in the rat colon and affect the metabolome.Semantic proximity Read