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Sucralose Consumption Ablates Cancer Immunotherapy Response through Microbiome Disruption

30 Jul 2025

Abstract excerpt

Gut microbiota composition is directly associated with response to immunotherapies in cancer. The impact of diet on the gut microbiota and downstream immune responses to cancer remains unclear. In this study, we show that consumption of a common nonnutritive sweetener, sucralose, modifies microbiome composition, restricts T-cell metabolism and function, and limits immunotherapy response in preclinical models of...

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PMID: 40742298
DOI: 10.1158/2159-8290.cd-25-0247

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