Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

doi:10.1093/jnci/djw134

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Article

Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype.

Journal of the National Cancer Institute - 1 Nov 2016

McConechy Melissa K, Färkkilä Anniina, Horlings Hugo M, Talhouk Aline, Unkila-Kallio Leila, van Meurs Hannah S, Yang Winnie, Rozenberg Nirit, Andersson Noora, Zaby Katharina, Bryk Saara, Bützow Ralf, Halfwerk Johannes B G, Hooijer Gerrit K J, van de Vijver Marc J, Buist Marrije R, Kenter Gemma G, Brucker Sara Y, Krämer Bernhard, Staebler Annette, Bleeker Maaike C G, Heikinheimo Markku, Kommoss Stefan, Blake Gilks C, Anttonen Mikko, Huntsman David G

Abstract excerpt

The histopathologic features of adult granulosa cell tumors (AGCTs) are relatively nonspecific, resulting in misdiagnosis of other cancers as AGCT, a problem that has not been well characterized. FOXL2 mutation testing was used to stratify 336 AGCTs from three European centers into three categories: 1) FOXL2 mutant molecularly defined AGCT (MD-AGCT) (n = 256 of 336), 2) FOXL2 wild-type AGCT (n = 17 of 336), 3)...

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PMID: 27297428
DOI: 10.1093/jnci/djw134
PMCID: PMC5241905

Genes

FOXL2

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