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Article

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection.

The Journal of experimental medicine - 5 Jun 2017

Pallett Laura J, Davies Jessica, Colbeck Emily J, Robertson Francis, Hansi Navjyot, Easom Nicholas J W, Burton Alice R, Stegmann Kerstin A, Schurich Anna, Swadling Leo, Gill Upkar S, Male Victoria, Luong TuVinh, Gander Amir, Davidson Brian R, Kennedy Patrick T F, Maini Mala K

Abstract excerpt

The liver provides a tolerogenic immune niche exploited by several highly prevalent pathogens as well as by primary and metastatic tumors. We have sampled healthy and hepatitis B virus (HBV)-infected human livers to probe for a subset of T cells specialized to overcome local constraints and mediate immunity. We characterize a population of T-betloEomesloBlimp-1hiHobitlo T cells found within the intrahepatic but...

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Identifiers

PMID: 28526759
DOI: 10.1084/jem.20162115
PMCID: PMC5461007

Genes

CXCR3
CXCR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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