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Article

Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.

British journal of cancer - 1 Mar 2021

Culliford Richard, Cornish Alex J, Law Philip J, Farrington Susan M, Palin Kimmo, Jenkins Mark A, Casey Graham, Hoffmeister Michael, Brenner Hermann, Chang-Claude Jenny, Kirac Iva, Maughan Tim, Brezina Stefanie, Gsur Andrea, Cheadle Jeremy P, Aaltonen Lauri A, Dunlop Malcom G, Houlston Richard S

Abstract excerpt

BACKGROUND: Epidemiological studies of the relationship between gallstone disease and circulating levels of bilirubin with risk of developing colorectal cancer (CRC) have been inconsistent. To address possible confounding and reverse causation, we examine the relationship between these potential risk factors and CRC using Mendelian randomisation (MR). METHODS: We used two-sample MR to examine the relationship...

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Identifiers

PMID: 33414539
DOI: 10.1038/s41416-020-01211-x
PMCID: PMC7961009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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