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Article

Bidirectional Mendelian randomisation analysis of the relationship between circulating vitamin D concentration and colorectal cancer risk.

International journal of cancer - 15 Jan 2022

He Yazhou, Zhang Xiaomeng, Timofeeva Maria, Farrington Susan M, Li Xue, Xu Wei, Campbell Harry, Houlston Richard S, Tomlinson Ian P, Theodoratou Evropi, Dunlop Malcolm G

Abstract excerpt

Epidemiological evidence is consistent with a protective effect of vitamin D against colorectal cancer (CRC), but the observed strong associations are open to confounders and potential reverse causation. Previous Mendelian randomisation (MR) studies were limited by poor genetic instruments and inadequate statistical power. Moreover, whether genetically higher CRC risk can influence vitamin D level, namely the...

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PMID: 34449871
DOI: 10.1002/ijc.33779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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