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Cysteine and glycine-rich protein 2 is crucial for maintaining the malignant phenotypes of gliomas through its action on Notch signalling cascade.

Toxicology and applied pharmacology - 1 Jun 2024

Liu Lingtong, Li Fei, Zhang Lingxue, Cheng Yingying, Wu Lin, Tie Ru, Jiang Xiaobing, Gao Wenwen, Liu Bochuan, Wei Yao, Chang Pan, Xu Jun, Zhao Haikang, Zhang Liang

Abstract excerpt

Cysteine and glycine-rich protein 2 (CSRP2) is expressed differently in numerous cancers and plays a key role in carcinogenesis. However, the role of CSRP2 in glioma is unknown. This study sought to determine the expression profile and clinical significance of CSRP2 in glioma and explore its biological functions and mechanisms via lentivirus-mediated CSRP2 silencing experiments. Increased CSRP2 was frequently...

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PMID: 38744347
DOI: 10.1016/j.taap.2024.116969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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