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Article

Gene expression profiling distinguishes proneural glioma stem cells from mesenchymal glioma stem cells

14 Jul 2015

Abstract excerpt

Tumor heterogeneity of high-grade glioma (HGG) is recognized by four clinically relevant subtypes based on core gene signatures. However, molecular signaling in glioma stem cells (GSCs) in individual HGG subtypes is poorly characterized. Previously we identified and characterized two mutually exclusive GSC subtypes with distinct activated signaling pathways and biological phenotypes. One GSC subtype presented...

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PMID: 26251826
DOI: 10.1016/j.gdata.2015.07.007

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