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Article

Colorectal cancer risk variants rs10161980 and rs7495132 are associated with cancer survival outcome by a recessive mode of inheritance.

International journal of cancer - 1 Jun 2021

He Yazhou, Timofeeva Maria, Zhang Xiaomeng, Xu Wei, Li Xue, Din Farhat V N, Svinti Victoria, Farrington Susan M, Campbell Harry, Dunlop Malcolm G, Theodoratou Evropi

Abstract excerpt

Previous studies using additive genetic models failed to identify robust evidence of associations between colorectal cancer (CRC) risk variants and survival outcomes. However, additive models can be prone to false negative detection if the underlying inheritance mode is recessive. Here, we tested all currently known CRC-risk variants (n = 129) in a discovery analysis of 5675 patients from a Scottish cohort....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33411955
DOI: 10.1002/ijc.33465
PMCID: PMC8614120

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