Article
A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients.
European journal of cancer (Oxford, England : 1990) - 1 Dec 2021
Wills Christopher, He Yazhou, Summers Matthew G, Lin Yi, Phipps Amanda I, Watts Katie, Law Philip J, Al-Tassan Nada A, Maughan Timothy S, Kaplan Richard, Houlston Richard S, Peters Ulrike, Newcomb Polly A, Chan Andrew T, Buchanan Daniel D, Gallinger Steve, Marchand Loic L, Pai Rish K, Shi Qian, Alberts Steven R, Gray Victoria, West Hannah D, Escott-Price Valentina, Dunlop Malcolm G, Cheadle Jeremy P
Abstract excerpt
BACKGROUND: While genome-wide association studies (GWAS) have identified germline variants influencing the risk of developing colorectal cancer (CRC), there has been limited examination of the possible role of inherited variation as a determinant of patient outcome. PATIENTS AND METHODS: We performed a GWAS for overall survival (OS) in 1926 patients with advanced CRC from the COIN and COIN-B clinical trials. For...
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