Article
SALL4 controls cell fate in response to DNA base composition.
Molecular cell - 18 Feb 2021
Pantier Raphaël, Chhatbar Kashyap, Quante Timo, Skourti-Stathaki Konstantina, Cholewa-Waclaw Justyna, Alston Grace, Alexander-Howden Beatrice, Lee Heng Yang, Cook Atlanta G, Spruijt Cornelia G, Vermeulen Michiel, Selfridge Jim, Bird Adrian
Abstract excerpt
Mammalian genomes contain long domains with distinct average compositions of A/T versus G/C base pairs. In a screen for proteins that might interpret base composition by binding to AT-rich motifs, we identified the stem cell factor SALL4, which contains multiple zinc fingers. Mutation of the domain responsible for AT binding drastically reduced SALL4 genome occupancy and prematurely upregulated genes in...
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