Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.

eLife - 1 Aug 2018

Donovan Katherine A, An Jian, Nowak Radosław P, Yuan Jingting C, Fink Emma C, Berry Bethany C, Ebert Benjamin L, Fischer Eric S

Abstract excerpt

In historical attempts to treat morning sickness, use of the drug thalidomide led to the birth of thousands of children with severe birth defects. Despite their teratogenicity, thalidomide and related IMiD drugs are now a mainstay of cancer treatment; however, the molecular basis underlying the pleiotropic biology and characteristic birth defects remains unknown. Here we show that IMiDs disrupt a broad...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryonic Stem Cells
Share to Heart Defects, Congenital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Septal Defects, Atrial

Share to Peptide Hydrolases

Share to Proteolysis

Share to Teratogens

Share to Thalidomide

Share to Upper Extremity Deformities, Congenital

Source

Open in PubMed Open full text

Identifiers

PMID: 30067223
DOI: 10.7554/eLife.38430
PMCID: PMC6156078

Genes

SALL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.PMID 30067223Read ↗

SALL4 mediates teratogenicity as a thalidomide-dependent cereblon substrate.Semantic proximity Read ↗

A novel de novo nonsense mutation in SALL4 causing duane radial ray syndrome: a case report and expanding the phenotypic spectrum.Semantic proximity Read ↗

SALL4 mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders.Semantic proximity Read ↗

A novel de novo nonsense mutation in SALL4 causing duane radial ray syndrome: A case report and expanding the phenotypic spectrumSemantic proximity Read ↗

SALL4: engine of cell stemness.Semantic proximity Read ↗

A de novo mutation of SALL4 in a Chinese family with Duane Radial Ray Syndrome and expanding the phenotypic spectrumSemantic proximity Read ↗

A de novo mutation of SALL4 gene in a Chinese family with Okihiro syndromeSemantic proximity Read ↗

Duane radial ray syndrome (Okihiro syndrome) maps to 20q13 and results from mutations in SALL4, a new member of the SAL family.Semantic proximity Read ↗

Structural analysis of SALL4 zinc-finger domain reveals a link between AT-rich DNA binding and Okihiro syndromeSemantic proximity Read ↗

Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome.Semantic proximity Read ↗

Structure of SALL4 zinc finger domain reveals link between AT-rich DNA binding and Okihiro syndrome.Semantic proximity Read ↗

Tetramerisation governs SALL transcription factor function in development and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.