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The regulatory repertoire of PLZF and SALL4 in undifferentiated spermatogonia

1 Jan 2016

Abstract excerpt

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is poorly understood. The transcription factors Sal-like 4 (SALL4) and promyelocytic leukemia zinc finger (PLZF; also known as ZBTB16) are known to be required for normal SSC function, but their targets are largely unknown. ChIP-seq in...

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PMID: 27068105
DOI: 10.1242/dev.132761

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